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Biological studies of organotin(IV) complexes with 2-mercaptopyrimidine

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Abstract

The known organotin(IV) complexes with 2-mercaptopyrimidine (L) [Me2SnL2] (1), [Bun 2SnL2] (2), [Ph2SnL2] (3), and [Ph3SnL] (4) were synthesized using a new approach. The effect of the synthesized compounds on peroxidation of fatty acids (oleic and linoleic) was studied. Complexes 1–4 promote the peroxidation of oleic acid. Their effect on the enzymatic peroxidation of linoleic acid with lipoxygenase was compared with that of cisplatin and in vitro cytoxicity against sarcoma cancer cells was determined. The antiproliferative effect of complexes 2–4 was demonstrated.

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Authors and Affiliations

  1. Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece

    M. N. Xanthopoulou, S. K. Hadjikakou, N. Hadjiliadis & N. Kourkoumelis

  2. Department of Chemistry, M. V. Lomonosov Moscow State University, 1 Leninskie Gory, 119992, Moscow, Russian Federation

    E. R. Milaeva, Yu. A. Gracheva & V. Yu. Tyurin

  3. Department of Experimental Physiology, Medical School, University of Ioannina, 45110, Ioannina, Greece

    I. Verginadis, S. Karkabounas & M. Baril

  4. Department of Chemistry, McGill University, 801 Sherbrooke, Montreal, Quebec, Canada, H2A 2K6

    I. S. Butler

Authors
  1. M. N. Xanthopoulou
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  2. S. K. Hadjikakou
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  3. N. Hadjiliadis
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  4. N. Kourkoumelis
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  5. E. R. Milaeva
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  6. Yu. A. Gracheva
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  7. V. Yu. Tyurin
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  8. I. Verginadis
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  9. S. Karkabounas
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  10. M. Baril
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  11. I. S. Butler
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Corresponding authors

Correspondence to S. K. Hadjikakou, N. Hadjiliadis or E. R. Milaeva.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 737–743, April, 2007.

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Xanthopoulou, M.N., Hadjikakou, S.K., Hadjiliadis, N. et al. Biological studies of organotin(IV) complexes with 2-mercaptopyrimidine. Russ Chem Bull 56, 767–773 (2007). https://doi.org/10.1007/s11172-007-0115-z

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  • DOI: https://doi.org/10.1007/s11172-007-0115-z

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