Abstract
The intramolecular electrophilic substitution in 6-functionalized 1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-diones was used for the synthesis of pyrimido[4′,5′:3,4]-pyrrolo[1,2-a]quinoxaline-8,10(7H,9H)-dione, pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,2,4]benzo-triazine-8,10(7H,9H)-dione, and 2H-pyrimido[4′,5′:3,4]pyrrolo[1,2-a]indole-2,4,11(1H, 3H)-trione derivatives.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 12, pp. 2180–2185, December, 2006.
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Tsupak, E.B., Shevchenko, M.A. [3,4]-annulated pyrroles 1. Polynuclear heterocyclic systems based on pyrrolo[3,4-d]pyrimidine-2,4-dione. Russ Chem Bull 55, 2265–2270 (2006). https://doi.org/10.1007/s11172-006-0581-8
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DOI: https://doi.org/10.1007/s11172-006-0581-8
Key words
- 1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-diones
- heterocyclization
- electrophilic substitution
- acylation
- pyrimido[4′,5′:3,4]pyrrolo[1,2-a]quinoxaline-8,10(7H,9H)-diones
- diazotization
- pyrimido[4′,5′:3,4]pyrrolo[2,1-c][1,2,4]benzotriazine-8,10(7H,9H)-diones
- 2H-pyrimido[4′,5′:3,4]pyrrolo[1,2-a]indole-2,4,11(1H,3H)-triones
- 1H NMR spectroscopy
- anisotropic effect