Abstract
A combination of N-hydroxysuccinimide and p-toluenesulfonic acid is proposed as an efficient catalyst for the preparation of a great variety of imidazo[1,2-a]pyridine derivatives by three-component condensation of aromatic isocyanides, aldehydes, and 2-aminopyridine. The advantages of this procedure are high yields of the target products and the absence of side reactions.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1768–1772, October, 2006.
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Mironov, M.A., Tokareva, M.I., Ivantsova, M.N. et al. New catalytic system for the synthesis of imidazo[1,2-a]pyridines by the Ugi reaction. Russ Chem Bull 55, 1835–1839 (2006). https://doi.org/10.1007/s11172-006-0494-6
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DOI: https://doi.org/10.1007/s11172-006-0494-6