Abstract
The heats of dissolution of tetramethyl-bis-carbamide (the pharmaceutical Mebicarum) in H2O and D2O were measured at 288.15, 298.15, and 318.15 K using a sealed microcalorimeter with an isothermal shell. The error of measurements did not exceed 0.2%. The limiting molar enthalpies of dissolution Δsol H n ∞ and the H/D-isotope enthalpy effects of hydration δΔhydr H n ∞(H2O → D2O) were determined. Different effects of temperature on the pattern of variation of δΔ hydr H n ∞ were found: when T ≤ 315 K, this value is positive and decreases with T, while for T ≥ 315 K, hydration of tetramethyl-bis-carbamide upon replacement of H2O by D2O progressively becomes less endothermic.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 715–717, April, 2006.
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Ivanov, E.V., Abrosimov, V.K. & Batov, D.V. Effect of temperature on the H/D-isotope effects in the enthalpy of hydration of tetramethyl-bis-carbamide. Russ Chem Bull 55, 741–743 (2006). https://doi.org/10.1007/s11172-006-0323-y
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DOI: https://doi.org/10.1007/s11172-006-0323-y