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Mannich reaction in the synthesis of N,S-containing heterocycles. 1. Synthesis of novel derivatives of imidazo[2,1-b][1,3,5]thiadiazine

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Abstract

Reactions of (Z)-5-benzylidene-2-thiohydantoin with formaldehyde and primary aromatic amines afforded novel derivatives of imidazo[2,1-b][1,3,5]thiadiazine in 50–69% yields.

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Authors and Affiliations

  1. V. Dal’ East-Ukrainian National University, 20a kv. Molodezhnyi, 91034, Lugansk, Ukraine

    K. A. Frolov, V. V. Dotsenko & S. G. Krivokolysko

  2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    V. P. Litvinov

Authors
  1. K. A. Frolov
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  2. V. V. Dotsenko
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  3. S. G. Krivokolysko
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  4. V. P. Litvinov
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Dedicated to Academician N. S. Zefirov on the occasion of his 70th birthday.

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 2158–2160, September, 2005.

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Frolov, K.A., Dotsenko, V.V., Krivokolysko, S.G. et al. Mannich reaction in the synthesis of N,S-containing heterocycles. 1. Synthesis of novel derivatives of imidazo[2,1-b][1,3,5]thiadiazine. Russ Chem Bull 54, 2226–2228 (2005). https://doi.org/10.1007/s11172-006-0102-9

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  • DOI: https://doi.org/10.1007/s11172-006-0102-9

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