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The synthesis of imidodiphosphoric acid derivatives as potential substrates in the pyrophosphorolysis reaction

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Abstract

The preparation conditions for dichlorophosphinylphosphorimidic trichloride were optimized. It was used in the synthesis of esters of imidodiphosphoric acid. The interaction of the trichloride with amines resulted in the corresponding amidodiphosphates rather than in the expected amides of imidodiphosphoric acid.

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Abbreviations

HIV:

human immunodeficiency virus

RT:

reverse transcriptase

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Correspondence to N. F. Zakirova.

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Translated from Bioorganicheskaya Khimiya, Vol. 31, No. 1, 2005, pp. 96–102.

Original Russian Text Copyright © 2005 by Zakirova, Golubeva, Shipitsin, Aleksandrova.

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Zakirova, N.F., Golubeva, N.A., Shipitsin, A.V. et al. The synthesis of imidodiphosphoric acid derivatives as potential substrates in the pyrophosphorolysis reaction. Russ J Bioorg Chem 31, 87–93 (2005). https://doi.org/10.1007/s11171-005-0012-x

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  • DOI: https://doi.org/10.1007/s11171-005-0012-x

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