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Modification of hyaluronic acid with aromatic amino acids

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Abstract

Hyaluronic acid was modified with aromatic amino acids (5-aminosalicylic, 4-aminosalicylic, anthranilic, and p-aminobenzoic) in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide. The modified glycans contained 9–43% of arylamide groups and 10–33% of isoureidocarbonyl groups depending on the nature of the amino acid. Reduction with sodium borohydride allowed the conversion of isoureidocarbonyl groups into hydroxymethyl groups.

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Abbreviations

DEAE-cellulose:

diethylaminoethylcellulose

EDC:

1-ethyl-3-[3-dimethylamino)propyl]carbodiimide

HA:

hyaluronic acid

TCA:

trichloroacetic acid

TBAH:

tetrabutylammonium hydroxide

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Authors and Affiliations

  1. Institute of Petrochemistry and Catalysis, Academy of Sciences of Bashkortostan and Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 141 Ufa, 450075, Bashkortostan, Russia

    I. Yu. Ponedel’kina, V. N. Odinokov, E. S. Vakhrusheva, M. T. Golikova, L. M. Khalilov & U. M. Dzhemilev

Authors
  1. I. Yu. Ponedel’kina
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  2. V. N. Odinokov
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  3. E. S. Vakhrusheva
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  4. M. T. Golikova
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  5. L. M. Khalilov
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  6. U. M. Dzhemilev
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Correspondence to I. Yu. Ponedel’kina.

Additional information

Translated from Bioorganicheskaya Khimiya, Vol. 31, No. 1, 2005, pp. 90–95.

Original Russian Text Copyright © 2005 by Ponedel’kina, Odinokov, Vakhrusheva, Golikova, Khalilov, Dzhemilev.

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Ponedel’kina, I.Y., Odinokov, V.N., Vakhrusheva, E.S. et al. Modification of hyaluronic acid with aromatic amino acids. Russ J Bioorg Chem 31, 82–86 (2005). https://doi.org/10.1007/s11171-005-0011-y

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  • DOI: https://doi.org/10.1007/s11171-005-0011-y

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