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An eco-friendly approach to synthesize arylmethylene bis(3-hydroxy-5,5’-dimethyl-2-cyclohexene-1-ones) and 1,8-dioxo-octahydroxanthenes

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Abstract

A new method has been proposed for the green and efficient synthesis of xanthenediones and their corresponding open-chain analogs aryl-methylene bis(3-hydroxy-5,5’-dimethyl-2-cyclohexene-1-ones) using natural acid, Lemon juice, as the catalyst. This method involves the use of lemon juice as a surfactant-type bronsted acid, which makes it non-polluting and produces a high-purity product with excellent yield. Additionally, the work-up procedure is clean and straightforward. Dimedone and aldehydes are the starting materials for this process.

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Acknowledgements

The authors would like to express their thankfulness to the Indian Institute of Chemical Technology (IICT), Hyderabad, for the NMR analysis.

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Authors and Affiliations

  1. Synthetic Research Laboratory, PG Department of Chemistry, PDVP College (Affiliated to Shivaji University, Kolhapur), Tasgaon, Sangli, Maharashtra, 416312, India

    Swati D. Jadhav, Bhagyashree M. Patil & Suresh S. Patil

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  1. Swati D. Jadhav
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Contributions

SDJ and SSP contributed equally to the experiment design and direction, with SDJ and BMP performing the laboratory work. The authors jointly prepared the draft manuscript, and finalized the manuscript.

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Correspondence to Swati D. Jadhav.

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Jadhav, S.D., Patil, B.M. & Patil, S.S. An eco-friendly approach to synthesize arylmethylene bis(3-hydroxy-5,5’-dimethyl-2-cyclohexene-1-ones) and 1,8-dioxo-octahydroxanthenes. Res Chem Intermed (2024). https://doi.org/10.1007/s11164-024-05274-w

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