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Green synthesis of substituted 1,8-naphthyridin-thiazole scaffolds, molecular docking studies and biological evaluation

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Abstract

Eco-friendly construction of N-(5-(2-methyl-1,8-naphthyridine)-thiazole-benzamide and 5-(2-methyl-1,8-naphthyridine)-N-(3-aryl-1,8-naphthyridine-thiazole-2-amine derivatives under microwave method afforded good yields in short reaction time with maximum selectivity compared with conventional method in the presence of triethylamine and, Pd(PPh3)4. This route can assimilate the concept of green chemistry because reaction process is very squatter reaction time and enhanced energy efficiency. Synthesized molecules are tested for their antimicrobial activity; among them, 7e and 7b compounds have shown good results and molecular modeling evaluation has been done by considering docking scores, hydrogen bond interactions, affinity, and the short distance between ligand and receptor. In silico studies also good complimented for these results.

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Acknowledgements

We express thanks to the Head of the Department of Chemistry, Osmania University, Hyderabad and Kakatiya Government College, Hanumakonda, for providing the laboratory facilities for research. Finally, the authors (Alishala Ashok) wish to express their gratitude to Central facilities research and development CFRD, Osmania University, for providing 1H and 13C NMR facilities.

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Authors and Affiliations

  1. Department of Chemistry, Osmania University, Hyderabad, Telangana, 500007, India

    Alishala Ashok & Boda Sakram

  2. Department of Chemistry, Indian Institute of Technology, NH-65, Nagaur Road, Karwar, Jodhpur, Rajasthan, India

    Banoth Sonyanaik

Authors
  1. Alishala Ashok
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  2. Banoth Sonyanaik
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  3. Boda Sakram
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Contributions

A A; Alishala Ashok did most of the research work and drafted the manuscript's first author. BS supplemented some data and checked references. BS suggested ideas, monitored the work, reviewed the manuscript, and finished it.

Corresponding author

Correspondence to Boda Sakram.

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Ashok, A., Sonyanaik, B. & Sakram, B. Green synthesis of substituted 1,8-naphthyridin-thiazole scaffolds, molecular docking studies and biological evaluation. Res Chem Intermed 49, 1029–1041 (2023). https://doi.org/10.1007/s11164-022-04951-y

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