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Revisit to Henry reaction by non conventional heterogeneous and efficient catalyst for nitroalcohol synthesis

Abstract

A sustainable, green and efficient process for the synthesis of 2-nitro alcohol derivatives from different substituted aromatic aldehydes with nitroalkane by stirring at ambient temperature with high product yield is reported. Adoption of very mild reaction conditions, use of Calcined Eggshell (CES) as natural catalyst and simple workup are expected to contribute to the development of environmentally benign synthetic method for Henry (nitroaldol) reaction. CES is ecologically safe, inexpensive, and attractive heterogeneous base catalyst obtained from renewable resources, thus opening a new perspective for this process.

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Acknowledgements

Authors Rupesh C. Patil and Ashutosh A. Jagdale are grateful to SARTHI, Pune for the award of CMSRF-2019 and CMNRF-2019 fellowship, respectively. [CIN-U74999PN2018NPL177394, dated 11th Sept. 2019]. Authors are also thankful to Indian Institute of Chemical Technology (IICT), Hyderabad for NMR analysis.

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Correspondence to Swati D. Jadhav.

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Jadhav, S.D., Patil, R.C., Jagdale, A.A. et al. Revisit to Henry reaction by non conventional heterogeneous and efficient catalyst for nitroalcohol synthesis. Res Chem Intermed (2021). https://doi.org/10.1007/s11164-021-04608-2

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Keywords

  • Calcined eggshell
  • Heterogeneous catalyst
  • Henry reaction
  • Nitro alcohol