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A new class of mixed ligand complexes bearing bisphenol and 1,10-Phenanthroline for antimicrobial and antioxidant activities: synthesis, spectral and electrochemical studies

Abstract

A new class of mixed ligand complexes, [M(L)(phen)2], using a bidentate bischlorophenol ligand H2L (2,2′-methylenebis(4-chlorophenol)) and phenanthroline has been synthesized. All the compounds were characterized by spectral (IR, UV, NMR and mass), magnetic, molar conductivity and cyclic voltammetry studies. The IR spectral data revealed that the bisphenol and phenanthroline ligands coordinate to the metal ions through the formation of M–O and M–N bonds. The electronic and magnetic data indicate the octahedral geometry of the complexes. The ESR spectrum of mononuclear copper complex shows four lines due to hyperfine splitting and the copper + 2 ion is present in octahedral environment. Cyclic voltammograms show two reduction potentials in cathodic direction. The first one at higher potential, − 1.05 to − 1.58 V, is due to the phenanthroline moiety and the second one at − 0.58 to − 0.65 V is due to the metal centered reduction potential. The antimicrobial activity of all the compounds was studied on some human pathogenic bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococci species) and fungi (Candida species, Aspergillus species). Copper complex 3 and cobalt complex 1 show higher antibacterial and antifungal activities, respectively, than the ligand and other complexes. The in-vitro antioxidant activity was spectrophotometrically studied by radical scavenging and reducing power activities. The biological activities of mixed ligand metal complexes are improved through synergistic effect of ligand, co-ligand and metal center.

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Acknowledgements

The authors are grateful for the financial support from the University Grants commission, Government of India, New Delhi, India (UGC-BSR, No: F. 30-319/2016).

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Correspondence to K. Shanmuga Bharathi.

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Indira, S., Vinoth, G., Bharathi, M. et al. A new class of mixed ligand complexes bearing bisphenol and 1,10-Phenanthroline for antimicrobial and antioxidant activities: synthesis, spectral and electrochemical studies. Res Chem Intermed 47, 3051–3065 (2021). https://doi.org/10.1007/s11164-021-04447-1

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Keywords

  • Bisphenol
  • Mixed ligand complexes
  • Magnetic study
  • Redox behavior
  • Antimicrobial and antioxidant studies