The design and synthesis of a novel chiral 1,1′-disubsitituted ruthenocenyl phosphine–oxazoline ligand

Abstract

Chiral ferrocene-based phosphine–oxazoline ligands have shown efficient asymmetric catalytic behaviors in asymmetric catalysis; however, the design and synthesis of the corresponding chiral ruthenocenes have not been widely explored. In this article, we report the synthesis of a chiral ruthenocene-based 1,1′-phosphine–oxazoline ligand, based on careful design and experimental exploration. The experimental results here reveal again that the synthetic preparation of 1,1′-disubstituted chiral ruthenocenyl ligands differs from the corresponding ferrocenes. The current method provides a feasible and practical strategy for the synthesis of 1,1′-disubstituted ruthenocene-based ligands.

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Acknowledgements

This work was supported by National Natural Science Foundation of China (No. 21672142, 21971162, 21831005, and 21620102003) and Shanghai Municipal Education Commission (No. 201701070002E00030). We also thank the Instrumental Analysis Center of SJTU for characterization.

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Correspondence to Delong Liu.

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Ye, J., Xu, Y., Li, J. et al. The design and synthesis of a novel chiral 1,1′-disubsitituted ruthenocenyl phosphine–oxazoline ligand. Res Chem Intermed 46, 5101–5115 (2020). https://doi.org/10.1007/s11164-020-04253-1

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Keywords

  • 1,1′-disubstituted ruthenocene
  • Phosphine–oxazoline ligand
  • Chirality
  • Synthesis