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Green synthesis of pyranopyrazoles via biocatalytic one-pot Knoevenagel condensation–Michael-type addition–heterocyclization cascade in non-aqueous media

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Abstract

An efficient, green and facile route for the one-pot four-component synthesis of pyranopyrazole derivatives through the condensation of the aromatic aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate using baker’s yeast as biocatalyst is presented. The important aspects of the present methodology are the use of an environmentally friendly catalyst, high yield of products and mild reaction conditions, i.e. at neutral pH and ambient temperature.

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Acknowledgements

We are very thankful to the Science and Engineering Research Board, New Delhi, for providing essential financial support (SERB/EMEQ-279/2013). We are also grateful to SAIF, NEHU, Shillong and CDRI, Lucknow, for providing spectral characterizations of our compounds.

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Authors and Affiliations

  1. Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, South Ambazari Road, Nagpur, Maharashtra, 440010, India

    Prabhakar Shrivas, Rajat Pandey, Sangesh Zodape, Atul Wankhade & Umesh Pratap

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  1. Prabhakar Shrivas
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  2. Rajat Pandey
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  3. Sangesh Zodape
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Correspondence to Umesh Pratap.

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Shrivas, P., Pandey, R., Zodape, S. et al. Green synthesis of pyranopyrazoles via biocatalytic one-pot Knoevenagel condensation–Michael-type addition–heterocyclization cascade in non-aqueous media. Res Chem Intermed 46, 2805–2816 (2020). https://doi.org/10.1007/s11164-020-04122-x

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