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One-pot, multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives containing ferrocenyl

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Abstract

A novel series of 4-(substituted phenyl)-6-ferrocenyl-3,4-dihydropyrimidin- 2(1H)-ones has been synthesized by the Biginelli reaction between different substituted aromatic aldehydes, acetylferrocene and urea in the presence of boric acid as a catalyst. In addition, the effects of different conditions on the reaction were explored. The structures of all the target compounds were confirmed by FT-IR, 1H NMR, and 13C NMR.

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Acknowledgements

The authors are indebted to Prof. Baojian Liu for his support and encouragement. The authors are thankful to Shaanxi University of Science & Technology for FT-IR spectroscopy and NMR spectroscopy.

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Authors and Affiliations

  1. Shaanxi Key Laboratory of Chemical Additives for Industry, Shaanxi University of Science and Technology, Xi’an, 710021, China

    Yuting Liu, Yang Dang, Dawei Yin, Xiaoming Yang, Lan Yang & Qian Zou

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  1. Yuting Liu
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  2. Yang Dang
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  3. Dawei Yin
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  4. Xiaoming Yang
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  5. Lan Yang
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  6. Qian Zou
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Correspondence to Yang Dang.

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Liu, Y., Dang, Y., Yin, D. et al. One-pot, multi-component synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives containing ferrocenyl. Res Chem Intermed 46, 547–555 (2020). https://doi.org/10.1007/s11164-019-03966-2

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  • DOI: https://doi.org/10.1007/s11164-019-03966-2

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