Skip to main content

Advertisement

SpringerLink
Log in

A novel chemosensor for Fe3+ based on open–closed-loop mechanism and imaging in living cells

  • Published:
Research on Chemical Intermediates Aims and scope Submit manuscript

Abstract

In this paper, a novel chemosensor (named L1) for Fe3+ based on the rhodamine 6G and o-vanillin has been synthesized, which can selectively recognize Fe3+. The L1 solution showed a distinguishable colour change by naked eye, and the fluorescence turns on response after the addition of Fe3+. In addition, the experimental results showed that the spirocyclic of L1 was opened by cooperation between L1 and Fe3+, and then the fluorescence emission after excitation of the mixture solution was detected with the change in solution colour. The complexation coefficient of L1 towards Fe3+ was 1:1. Furthermore, L1 for Fe3+ sensing had a remarkable low detection limit of 427 nM (UV) and 130 nM (fluorescence), which is far below the drinking water standards (0.3 mg/L) of China. Meanwhile, the in vivo imaging and cell viability assay experiments demonstrated that L1 could be used for sensing Fe3+ in vivo.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Scheme 2
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. B. Niu, K. Xiao, X. Huang et al., ACS Appl. Mater. Interfaces 10, 22632 (2018)

    Article  CAS  Google Scholar 

  2. Y. Wang, H.Q. Chang et al., Sens. Actuators B Chem. 239, 60 (2017)

    Article  CAS  Google Scholar 

  3. G. Zhang, B. Lu, Y. Wen et al., Sens. Actuators B Chem. 8, 786 (2012)

    Article  Google Scholar 

  4. C.T. Sempos, R.F. Gillum, A.C. Looker. Iron and Heart Disease. Preventive Nutrition (2005)

  5. S. Swaminathan, V.A. Fonseca, M.G. Alam et al., Diabetes Care 30, 1926 (2007)

    Article  CAS  Google Scholar 

  6. J.W. Eschch, J.W. Adaon, Kidney Int. 55, S35 (1999)

    Article  Google Scholar 

  7. M.E. Conrad, J.N. Umbreit, Am. J. Hematol. 64, 287 (2000)

    Article  CAS  Google Scholar 

  8. M.E. Conrad, J.N. Umbreit, Am. J. Med. Sci. 318, 213 (1999)

    Article  CAS  Google Scholar 

  9. S.W. Thomas, G.D. Joly, T.M. Swager, Chem. Rev. 107, 1339 (2007)

    Article  CAS  Google Scholar 

  10. Z.D. Tian, Y.C. Liu, B.Z. Tian, J.L. Zhang, Res. Chem. Intermed. 41, 525 (2015)

    Article  CAS  Google Scholar 

  11. D. Şahin, H. Yılmaz, Z. Hayvalı, Res. Chem. Intermed. 42, 6337 (2016)

    Article  Google Scholar 

  12. H. Wang, J. Li, D. Yao et al., Res. Chem. Intermed. 39, 2723 (2013)

    Article  CAS  Google Scholar 

  13. C. Wan, H. Li, J. Wang et al., Res. Chem. Intermed. 45, 1815 (2019)

    Article  CAS  Google Scholar 

  14. C.J. Li, K.Q. Xiang, Y.C. Liu et al., Res. Chem. Intermed. 41, 10169 (2015)

    Article  CAS  Google Scholar 

  15. R. Qiao, W.Z. Xiong, C.B. Bai et al., Supramol. Chem. 30, 911 (2018)

    Article  CAS  Google Scholar 

  16. T. Zhou, X.X. Chen, Q.H. Hua et al., Sens. Actuators B Chem. 253, 292 (2017)

    Article  CAS  Google Scholar 

  17. H. Kim, S. Wang, S.H. Kim et al., Mol. Cryst. Liq. Cryst. 566, 45 (2012)

    Article  CAS  Google Scholar 

  18. J.H. Chu, X.H. Xu, S.M. Kang, N. Liu, Z.Q. Wu, J. Am. Chem. Soc. 140, 17773 (2018)

    Article  CAS  Google Scholar 

  19. Z.Q. Jiang, S.Q. Zhao, Y.X. Su, N. Liu, Z.Q. Wu, Macromolecules 51, 737 (2018)

    Article  CAS  Google Scholar 

  20. M. Su, N. Liu, Q. Wang, H.Q. Wang, J. Yin, Z.Q. Wu, Macromolecules 49, 110 (2016)

    Article  CAS  Google Scholar 

  21. Z.Q. Hu, Y.Y. Gu, W.Z. Hu et al., Chemistryopen 3, 264 (2014)

    Article  CAS  Google Scholar 

  22. X.M. Li, R.R. Zhao, Y. Yang et al., Chin. Chem. Lett. 28, 1258 (2017)

    Article  CAS  Google Scholar 

  23. G.F. Chen, H.M. Jia, L.Y. Zhang et al., Res. Chem. Intermed. 39, 4081 (2013)

    Article  CAS  Google Scholar 

  24. L. Huang, F.P. Hou, J. Cheng et al., Org. Biomol. Chem. 10, 9634 (2012)

    Article  CAS  Google Scholar 

  25. C. Kar, M.D. Adhikari, A. Ramesh, G. Das, Inorg. Chem. 52, 743 (2013)

    Article  CAS  Google Scholar 

  26. Department of Water Resources Management, Quality Standard for Ground Water of the National Standards of the People’s Republic of China, GB 5749-2006, Department of Water Resources Management, China, (2007)

  27. Y. Gao, J. Wang, M. Fu, H.W. Chen, M.Z. Fang, J. Org. Chem. 37, 617 (2017)

    CAS  Google Scholar 

  28. H.Y. Jo, G.J. Park, Y.J. Na, Y.W. Choi, G.R. You, C. Kim, Dyes Pigments 109, 127 (2014)

    Article  CAS  Google Scholar 

  29. Z.P. Yu, C.H. Ma, Q. Wang, N. Liu, J. Yin, Z.Q. Wu, Macromolecules 49, 1180 (2016)

    Article  CAS  Google Scholar 

  30. S.Q. Zhao, G.J. Hu, X.H. Xu, S.M. Kang, N. Liu, Z.Q. Wu, ACS Macro Lett. 7, 1073 (2018)

    Article  CAS  Google Scholar 

  31. F. Zhou, T.H. Leng, Y.J. Liu et al., Dyes Pigments 142, 429 (2017)

    Article  CAS  Google Scholar 

  32. Q. Wang, L.P. Huang, X. Quan, Q.L. Zhao, J. Photochem. Photobiol. A 357, 156 (2018)

    Article  CAS  Google Scholar 

  33. L. Zhang, J.Y. Wang, J.L. Fan et al., Bioorg. Med. Chem. Lett. 21, 5413 (2011)

    Article  CAS  Google Scholar 

  34. W. Wang, J. Wu, Q. Liu et al., Tetrahedron Lett. 59, 1860 (2018)

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by key projects of Anhui Province University outstanding youth talent support program (gxyqZD2018078); Key Provincial Teaching and Research Projects in Anhui Province (2017jyxm0444); Innovation and Entrepreneurship Training Program for College Students (S201910375032).

Author information

Authors and Affiliations

  1. Department of Chemistry, Huangshan University, Huangshan, 245041, China

    Quan Zhou, Le Qian, Qianqian Pan, Guanqing Si, Zhaopeng Qi, Yuchuan Zheng & Changjiang Li

  2. Key Laboratory of Inorgnic Functional Material, Huangshan University, Huangshan, 245041, China

    Zhaopeng Qi, Yuchuan Zheng & Changjiang Li

Authors
  1. Quan Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Le Qian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Qianqian Pan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Guanqing Si
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zhaopeng Qi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yuchuan Zheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Changjiang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Yuchuan Zheng or Changjiang Li.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOC 1201 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhou, Q., Qian, L., Pan, Q. et al. A novel chemosensor for Fe3+ based on open–closed-loop mechanism and imaging in living cells. Res Chem Intermed 46, 533–545 (2020). https://doi.org/10.1007/s11164-019-03965-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11164-019-03965-3

Keywords

Search

Navigation