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A trinuclear Co(II) cluster-based metal–organic framework for selective gas sorption and protective effect on acute glomerulonephritis by inhibiting NF-κb pathway

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Abstract

By using a nanosized tetracarboxylate ligand 2,3,5,6-tetrakis(4-carboxyphenyl)pyrazine (H4TCPP) as a building block, the synthesis of a new microporous Co-based metal–organic framework was performed by making Co(NO2)3·6H2O and the presence of bpy ligand to react under solvothermal reaction, and its chemical formula is [Co3(OH)2(H2TCPP)2(bpy)](DMF)3 (1, bpy = 4,4ʹ-bipyridine). Gas adsorption studies reveal that the mixtures of C2H2/CH4 and C2H2/CO2 could be selectively separated by the obtained activated 1a. The protective effect of compound on AGN was further evaluated in vitro. The RT-PCR was carried out to determine the relative expression of tnf-α, nf-κb in glomerular cells after bacterial infection and compound treatment. The IL-1β and IL-18 content in glomerular cells was also evaluated by ELISA after compound treatment. Finally, the results obtained through molecular docking exhibited possible regulation mechanism on regulation of binding affinity between DNA and target protein.

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Author notes

  1. Heng-Yuan Zhang and Xing Chen have contributed equally to this article.

Authors and Affiliations

  1. Department of Nephropathy, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China

    Heng-Yuan Zhang, Xing Chen, Li-Jing Yao, Shi-Zhi Chen & Xue-Juan Sun

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  1. Heng-Yuan Zhang
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  2. Xing Chen
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  3. Li-Jing Yao
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  4. Shi-Zhi Chen
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  5. Xue-Juan Sun
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Correspondence to Heng-Yuan Zhang.

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Zhang, HY., Chen, X., Yao, LJ. et al. A trinuclear Co(II) cluster-based metal–organic framework for selective gas sorption and protective effect on acute glomerulonephritis by inhibiting NF-κb pathway. Res Chem Intermed 46, 521–532 (2020). https://doi.org/10.1007/s11164-019-03964-4

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