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Synthesis of Some Hybrid 7-Hydroxy Quinolinone Derivatives As Anti Breast Cancer Drugs

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Abstract

A new series of hybrid 2-Quinolinone derivatives were synthesized and structurally proved using spectral and elemental analyses data. All the prepared compounds were tested for their in vitro cytotoxic activity against MCF-7 cell line. Compounds 6 and 8 showed potent anticancer activity, which were comparable to Doxorubicin as reference compound. While compound 3 was comparable to cisplatin. Cell cycle analysis of compounds 6 and 8 showed cell cycle arrest at S and G2/M phases of the cycle and induced apoptosis at pre-G1 phase. DNA synthesis inhibitory activity demonstrated that compound 6 showed equipotent activity to Doxorubicin. The extent of apoptosis was also determined using Annexin V-FITC assay. In addition, compounds 6 and 8 increase the activation of effector caspase 3 by four fold more than untreated control. On the other hand, the localization of compounds 3, 6 and 8 were found in the nucleus.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt

    Amal Mahmoud Youssef Moustafa

  2. Faculty of Education, Shaqra University, Almuzahimiyah, Kingdom of Saudi Arabia

    Safyah B. Bakare

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  1. Amal Mahmoud Youssef Moustafa
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Correspondence to Amal Mahmoud Youssef Moustafa.

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Moustafa, A.M.Y., Bakare, S.B. Synthesis of Some Hybrid 7-Hydroxy Quinolinone Derivatives As Anti Breast Cancer Drugs. Res Chem Intermed 45, 3895–3912 (2019). https://doi.org/10.1007/s11164-019-03827-y

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