Abstract
A novel DABCO-based cationic surfactant [C18-Dabco][Br] has been easily synthesized by the reaction of DABCO and octadecyl bromide in acetonitrile at room temperature in excellent yield. The synthesized surfactant was fully characterized by various techniques like FT-IR, 1H NMR, 13C NMR, LC–MS and TGA-DTA analysis. Furthermore, the critical micelle concentration of the surfactant was determined by the conductivity measurement method. The activity of the [C18-Dabco][Br] has been demonstrated for the one-pot synthesis of spirocarbocycles under ultrasonic conditions in water. The presence of the long alkyl chain acts as the hydrophobic part while the free tertiary nitrogen site in the surfactant acts as a base and enhances the overall catalytic activity.
Similar content being viewed by others
References
V.G. Santos, M.N. Godoi, T. Regiani, F.H.S. Gama, M.B. Coelho, R.A. de Souza, M.N. Eberlin, S.J. Garden, Chem. Eur. J. 20, 12808 (2014)
B. Voigt, M. Linke, R. Mahrwald, Org. Lett. 17, 2606 (2015)
A. Domling, Chem. Rev. Chem. Rev. 106, 17 (2006)
N. Shapiro, M. Kramer, I. Goldberg, A. Vigalok, Green Chem. 12, 582 (2010)
R.A. Sheldon, Green Chem. 7, 267 (2005)
A. Chanda, V.V. Fokin, Chem. Rev. 109, 725 (2009)
H.C. Hailes, Org. Process Res. Dev. 11, 114 (2007)
M. Barge, S. Kamble, A. Kumbhar, G. Rashinkar, R. Salunkhe, Monatsh. Chem. 144, 1213 (2013)
M. Shiri, M. A. Zolfigol, Tetrahedron 65, 587 (2009)
B. Lindman, H. Wennerstrom, Micelles Amphiphile Aggregation in Aqueous solution (Spinger, New York, 1980)
A. Goldsipe, D. Blankschtein, Langmuir 22, 9894 (2006)
R. Engel, J.I. Rizzo, C. Rivera, M. Ramirez, M.L. Huang, D. Montenegro, C. Copodiferro, V. Behaj, M. Thomas, B. Klaritch-Vrana, J.F. Engel, Chem. Phys. Lipids 158, 61 (2009)
R. Barney, J. Carroll, D. Delaet, J. Surfactants Deterg. 9, 137 (2006)
A. Dandia, R. Singh, S. Bhaskaran, S. Samant, Green Chem. 13, 1852 (2011)
B. Chen, J. Li, G. Chen, Ultrason. Sonochem. 23, 59 (2015)
Y. Peng, Q. Zhang, J. Yuan, J. Cheng, Chin. J. Chem. 26, 2228 (2008)
A.S. Girgis, Eur. J. Med. Chem. 44, 91 (2009)
R. Murugan, S. Anbazhagan, S.S. Narayanan, Eur. J. Med. Chem. 44, 3272 (2009)
S.A. Van der Sar, J.W. Blunt, M.H. Munro, Org. Lett. 8, 2059 (2006)
P. Prasanna, K. Balamurugan, S. Perumal, P. Yogeeswari, D. Sriram, Eur. J. Med. Chem. 45, 5653 (2010)
K.M. Amin, M.M. Kamel, M.M. Anwar, M. Khedr, Y.M. Syam, Eur. J. Med. Chem. 45, 2117 (2010)
B. Thadhaney, D. Sain, G. Pernawat, G.L. Talesara, Indian J. Chem. 49, 368 (2010)
X.Q. Chen, T. Pradhan, F. Wang, J.S. Kim, J. Yoon, Chem. Rev. 112, 1910 (2012)
B.M. Trost, N. Cramer, S.M. Silverman, J. Am. Chem. Soc. 129, 12396 (2007)
T. Lanza, R. Leardini, M. Minozzi, D. Nanni, P. Spagnolo, G. Zanardi, Angew. Chem. Int. Ed. 47, 9439 (2008)
M.N. Elinson, A.I. Ilovaisky, V.M. Merkulova, F. Barba, B. Batanero, Tetrahedron 69, 7125 (2013)
M. Rajeswari, P. Saluja, J.M. Khurana, RSC Adv. 6, 1307 (2016)
N. Sudhapriya, P.T. Perumal, C. Balachandran, S. Ignacimuthu, M. Sangeetha, M. Doble, Eur. J. Med. Chem. 83, 190 (2014)
G. Khanna, P. Saluja, J.M. Khurana, Tetrahedron Lett. 57, 5852 (2016)
S. Jadhav, A. Kumbhar, C. Rode, R. Salunkhe, Green Chem. 18, 1898 (2016)
A. Kumbhar, S. Kamble, M. Barge, G. Rashinkar, R. Salunkhe, Tetrahedron Lett. 53, 2756 (2012)
T. Lohar, A. Kumbhar, M. Barge, R. Salunkhe, J. Mol. Liq. 224, 1102 (2016)
A. Kumbhar, S. Kamble, S. Jadhav, G. Rashinkar, R. Salunkhe, Catal. Lett. 142, 1388 (2012)
Acknowledgement
One of the authors, Mr. Trushant Lohar, is very grateful to the Department of Science and Technology (DST), New Delhi, for awarding a DST-INSPIRE Fellowship (IF 140918).
Author information
Authors and Affiliations
Corresponding author
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Lohar, T., Kumbhar, A., Patil, A. et al. Synthesis and characterization of new quaternary ammonium surfactant [C18-Dabco][Br] and its catalytic application in the synthesis of spirocarbocycles under ultrasonic condition. Res Chem Intermed 45, 1639–1651 (2019). https://doi.org/10.1007/s11164-018-3690-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11164-018-3690-8