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Synthesis of multiple boron-containing analogs via Ugi-4CR

Abstract

One of the most significant challenges in boron neutron capture therapy (BNCT) is to have an ideal boron delivery agent which can deliver sufficient numbers of boron atoms to designated tumor cells. In this work, mild synthetic conditions for synthesis of dipeptidyl multiple boron-containing analogs under microwave-assisted condition were investigated. The results showed that the reaction generally took place at 50 °C, but higher reaction temperature was required when a fluorinated building block was used. The resulting peptidyl skeletons generated by Ugi four-component reaction resemble basic cell metabolites and could potentially be used as alternative replacements for current boron carrier agents in BNCT.

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Acknowledgements

This research was supported by the Ministry of Science and Technology in Taiwan (MST-104-2113-M-032-011, MST-105-2113-M-032-002). We thank the Department of Chemistry of Tamkang University for equipment and financial support. We thank Ms. Shen–Shen Chen for conducting 11B NMR experiments.

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Correspondence to Po-Shen Pan.

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Chen, YW., Liao, PC., Zhang, YX. et al. Synthesis of multiple boron-containing analogs via Ugi-4CR. Res Chem Intermed 45, 103–118 (2019). https://doi.org/10.1007/s11164-018-3629-0

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  • DOI: https://doi.org/10.1007/s11164-018-3629-0

Keywords

  • Boron neutron capture therapy
  • Boron
  • Multicomponent reaction
  • Ugi reaction