Tetrazole- and nitrile-containing bimesitylene derivatives with potential use in coordination chemistry were synthesized and characterized, and their structural particularities are discussed. For the bimesitylene bistetrazole derivative, geometry optimization was carried out by quantum-chemical calculations using density functional theory together with vibrational frequencies, natural bond orbitals, and highest occupied molecular orbital (HOMO)–lowest unoccupied molecular orbital (LUMO) calculations. The newly synthesized bimesitylene derivatives were also evaluated for their antimicrobial activity against three different reference strains, namely Escherichia coli, Staphylococcus aureus, and Candida albicans.
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Financial support from the European Social Fund for Regional Development, Competitiveness Operational Programme Axis 1—Project “Novel Porous Coordination Polymers with Organic Ligands of Variable Length for Gas Storage,” POCPOLIG (ID P_37_707, Contract 67/08.09.2016, cod MySMIS: 104810) is gratefully acknowledged. The research related to computational chemistry is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 667387 WIDESPREAD 2-2014 SupraChem Lab.
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Bahrin, L.G., Clima, L., Shova, S. et al. Synthesis, structure, computational modeling, and biological activity of two novel bimesitylene derivatives. Res Chem Intermed 45, 453–469 (2019). https://doi.org/10.1007/s11164-018-3611-x
- Bimesitylene derivatives
- Antimicrobial activity