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Sulfonylation of C(sp3)–H bond for synthesis of 2-sulfolmethyl azaarenes catalyzed by TBAI in water

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Abstract

A tetrabutylammonium iodide (TBAI)-catalyzed method for synthesis of 2-sulfolmethyl quinolone has been developed. Using water as solvent, a wide range of 2-sulfolmethyl quinolones were obtained in high to excellent yield. In addition, water and TBAI could be reused for five times without significant decrease of the yield of the corresponding product.

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Acknowledgements

We gratefully acknowledge financial support from the National Natural Science Foundation of China (21402103, 21772107), China Postdoctoral Science Foundation (150030), and Research Fund of Qingdao Agricultural University’s Highlevel Person (631303).

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Authors and Affiliations

  1. College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, 266109, People’s Republic of China

    Dao-Qing Dong, Li-Xia Li, Shuang-Hong Hao & Zu-Li Wang

  2. School of Chemical and Biological Engineering, Qilu Institute of Technology, Jinan, 250200, People’s Republic of China

    Xing Gao

Authors
  1. Dao-Qing Dong
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  2. Xing Gao
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  3. Li-Xia Li
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  4. Shuang-Hong Hao
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  5. Zu-Li Wang
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Correspondence to Zu-Li Wang.

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Dong, DQ., Gao, X., Li, LX. et al. Sulfonylation of C(sp3)–H bond for synthesis of 2-sulfolmethyl azaarenes catalyzed by TBAI in water. Res Chem Intermed 44, 7557–7567 (2018). https://doi.org/10.1007/s11164-018-3573-z

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  • DOI: https://doi.org/10.1007/s11164-018-3573-z

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