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Nano-ovalbumin: a green biocatalyst for biomimetic synthesis of tetrahydrodipyrazolo pyridines in water

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Abstract

In this investigation, a simple and new protocol was used to prepare large quantities of purified nano-ovalbumin from egg white. Nano-ovalbumin, as a retrievable and metal-free biocatalyst, was characterized by FT-IR, FESEM, XRD, MALDI-TOF and TGA/DTA. This biocatalyst displayed a high activity for green and efficient synthesis of tetrahydrodipyrazolo pyridines via multi-component reaction of ethyl acetoacetate, hydrazine, aldehyde and ammonium acetate in water. This new bio-catalyzed process could serve as a valuable synthetic alternative for such multi-component reactions in terms of economic aspects and biocompatibility of conditions.

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Acknowledgements

The Research Council of Yazd University is gratefully acknowledged for the financial support for this work.

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Correspondence to Bi Bi Fatemeh Mirjalili.

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Salehi, N., Mirjalili, B.B.F. Nano-ovalbumin: a green biocatalyst for biomimetic synthesis of tetrahydrodipyrazolo pyridines in water. Res Chem Intermed 44, 7065–7077 (2018). https://doi.org/10.1007/s11164-018-3542-6

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  • DOI: https://doi.org/10.1007/s11164-018-3542-6

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