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Research on Chemical Intermediates

, Volume 44, Issue 9, pp 5169–5180 | Cite as

A novel BF2–curcumin-based fluorescent chemosensor for detection of Cu2+ in aqueous solution and living cells

  • Yuan Li
  • Yu-Xin Ji
  • Lin-Jiang Song
  • Yi Zhang
  • Zi-Cheng Li
  • Li Yang
  • Wen-Cai Huang
Article
  • 132 Downloads

Abstract

A novel BF2–curcumin-based chemosensor 1, namely monopicolinate of BF2–curcumin complex, was designed, synthesized and applied for the detection of Cu2+ in aqueous buffer solution and living cells. Sensor 1 exhibited sensitive naked-eye color change toward Cu2+ from blue to pink in TBS solution and the detection limit was estimated to be 0.12 µM. The selectivity of sensor 1 for Cu2+ was high over competing metal ions (Ag+, Cu+, Hg2+, Mg2+, Ca2+, Co2+, Zn2+, Mn2+, Ni2+, Fe2+ and Fe3+). Based on the experimental results, the sensing mechanism was proposed for the Cu2+ triggered hydrolysis of 1 to BF2–curcumin which has unique chromogenic and fluorogenic properties. Compared with other chemosensors with a similar mechanism, chemosensor 1 had a comparatively large Stokes shift and the emission wavelength was close to NIR. Moreover, cell imaging investigations indicated that sensor 1 has the potential to be applied for practical Cu2+ detection in biological systems.

Keywords

Cu2+ detection Chemosensor Curcumin Naked eye Picolinate 

Notes

Acknowledgements

We thank the Analytical and Testing Center of Sichuan University for NMR measurements.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11164_2018_3416_MOESM1_ESM.docx (490 kb)
Supplementary material 1 (DOCX 489 kb)

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pharmaceutical and Bioengineering, School of Chemical EngineeringSichuan UniversityChengduChina
  2. 2.Cancer CenterWest China Hospital, Sichuan University and Collaborative Innovation CenterChengduChina

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