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Research on Chemical Intermediates

, Volume 44, Issue 5, pp 3549–3564 | Cite as

Synthesis and in vitro and in silico antimicrobial studies of novel piperine–pyridine analogs

  • Karteek Rao Amperayani
  • Kottakki Naveen Kumar
  • Uma Devi Parimi
Article
  • 111 Downloads

Abstract

Pepper is used as a food additive and preservatives because of its antimicrobial activity. Piperine, an alkaloid amide derived from pepper, is the cause of its biological activity. Aminopyridine is a well-known antimicrobial agent. In silico studies proved that conjugation of piperine with substituted aminopyridine results in a new hybrid molecule with improved antimicrobial activity compared with the parent molecules. The present work describes design and synthesis of novel piperine analogs with substituted aminopyridine analogs (PY18). The synthesized compounds were characterized by 1H and 13C nuclear magnetic resonance (NMR), infrared (IR), and mass spectroscopy and subjected to antimicrobial testing using bacterial strains Bacillus subtilis, Streptobacillus, Staphylococcus aureus, Escherichia coli, and Salmonella typhi and fungal strains Aspergillus niger, A. flavus, and A. fumigatus.

Keywords

Piperine Aminopyridine Antimicrobial activity In silico studies 

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemistry, GITAM Institute of SciencesGITAM UniversityVisakhapatnamIndia

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