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Research on Chemical Intermediates

, Volume 44, Issue 5, pp 3475–3491 | Cite as

One-pot green synthesis and bio-assay of pyrazolylphosphonates

  • Gundluru Mohan
  • Sarva Santhisudha
  • Sudileti Murali
  • Nemallapudi Bakthavatchala Reddy
  • Gundala Sravya
  • Grigory V Zyryanov
  • Cirandur Suresh Reddy
Article
  • 102 Downloads

Abstract

An efficient one-pot synthesis of bioactive pyrazolylphosphonates is accomplished by the reaction of 3-methyl-1-phenyl-2-pyrazoline-5-one with various aryl aldehydes and diethyl phosphite in the presence of β-cyclodextrin (β-CD) as a catalyst. The compounds were tested for their anti-oxidant activity by DPPH and H2O2 radical scavenging assay and for anticancer activity against breast cancer (MCF-7), prostate cancer (DU-145) and lung cancer (A-549) cell lines with sulfarodamine-B (SRB) assay. Most of the synthesized compounds showed promising anti-oxidant activity and significant anticancer activity when compared with the standard drugs.

Keyword

Pyrazolylphosphonates Green synthesis β-cyclodextrin Anti-oxidant activity Anticancer activity 

Notes

Acknowledgements

The authors are grateful to Prof. C. Devendranath Reddy, Department of Chemistry, S.V. University, Tirupati, for his helpful discussions and acknowledge the funding support from DST-SERB, New Delhi, India, through Project No. SB/S1/OC-96/2013, Dt. 05-11-2014. One of the authors Dr. S. Santhisudha expresses sincere thanks to the Science and Engineering Research Board (SERB), New Delhi, India, for providing financial assistance (DST No: PDF/2016/000102, Dt: 11-07-2016). The corresponding author, Prof. C. Suresh Reddy, being an associate member of Institute of Food Security and Sustainable Agriculture, University Malaysia Kelantan, Jeli Campus, Malaysia, expresses his sincere thanks to University Malaysia Kelantan for their timely encouragement in our research work.

Supplementary material

11164_2018_3319_MOESM1_ESM.doc (8.3 mb)
Supplementary material 1 (DOC 8527 kb)

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistrySri Venkateswara UniversityTirupatiIndia
  2. 2.Department of ChemistryDravidian UniversityKuppamIndia
  3. 3.Department of Organic and Biomolecular Chemistry, Chemical Engineering InstituteUral Federal UniversityYekaterinburgRussian Federation
  4. 4.I.Ya. Postovskiy Institute of Organic SynthesisUral Division of the Russian Academy of SciencesYekaterinburgRussian Federation

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