Research on Chemical Intermediates

, Volume 44, Issue 5, pp 3337–3348 | Cite as

Metal free green protocol for the synthesis of bis-spiro piperidine and pyrimidine derivatives

  • Audumbar Patil
  • Rajashri SalunkheEmail author


A highly efficient one-pot three-component synthesis of bis-spiro piperidine and pyrimidine derivatives has been reported by performing the reaction of formaldehyde, aromatic aniline and 1,3-dicarbonyl compounds. This reaction was carried out at room temperature in 2,2,2-trifluoroethanol (TFE) as a recyclable reaction medium under the metal free condition. The strong hydrogen donor ability and acidic property of TFE plays a key role in accelerating the rate of reaction and initiates the reaction smoothly. The advantageous features of this method are a mild reaction condition, no column chromatographic purification, and high yield of products and recyclability of TFE.

Graphical Abstract


2,2,2-Trifluoroethanol Bis-spiro piperidine 1,3-Diaryl-hexahydropyrimidine Multicomponent reaction Green synthesis Reusability 



We gratefully acknowledge the financial support from the Department of Science and Technology and University Grants Commission, New Delhi, India.

Supplementary material

11164_2018_3310_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 13 kb)


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistryShivaji UniversityKolhapurIndia

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