Solvent-free synthesis of Ser–His dipeptide from non-activated amino acids and its potential function as organocatalyst

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Abstract

Short homopeptides (up to 3-mer) of serine and histidine, as well as Ser–His and His–Ser hetero-dipeptides, are produced from non-activated amino acids by using facile chemical vapor deposition and TiO2 nanoparticles as catalyst. The assessment of the formation of peptides is based on spectroscopic data such as in situ FT-IR and mass spectrometry. Evidence of the capability of Ser–His to promote hydrolysis of peptide bonds in hexaglycine is provided, contributing to the debate on the effectiveness of this dipeptide as an organocatalyst.

Keywords

FT-IR of adsorbed species Peptides Serine Histidine CVD 

Notes

Acknowledgements

This work was carried out in the frame of the project DAMA_RILO_16_01, funded by the University of Torino.

Supplementary material

11164_2017_3198_MOESM1_ESM.docx (853 kb)
Supplementary material 1 (DOCX 853 kb)

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of Science and High TechnologyUniversity of InsubriaComoItaly
  2. 2.Department of ChemistryUniversity of TorinoTurinItaly

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