Research on Chemical Intermediates

, Volume 44, Issue 3, pp 1745–1753 | Cite as

In vitro α-glucosidase and α-amylase inhibition, and in vivo anti-hyperglycemic effects of Psidium littorale Raddi leaf extract

  • Quang Vinh Nguyen
  • San-Lang Wang
  • Anh Dzung Nguyen


Guava, belonging to family Myrtaceae, is widely grown in tropical countries. Different parts of guava are reported to have long been used in folk medicine. In this study, the in vitro and in vivo anti-hyperglycemic activities of Psidium littorale Raddi leaves extract were investigated. The results indicated that the leaf extract demonstrates relatively high intestinal α-glucosidase inhibitory activity in rats, twice as high as acarbose. In addition, the extract also induced lowering fasting blood glucose levels in streptozotocin- induced diabetic rats at the dose of 150 mg/kg body weight, and without any effect on normal rats. Moreover, the extract did not significantly induce body weight loss in rats. The results suggest that P. littorale Raddi may prove to be useful in treating diabetes in humans.


Antidiabetic Psidium littorale Raddi DPPH α-amylase α-glucosidase 



We would like to express our thanks to the Department of Science and Technology, Dak Lak Province, Vietnam (2550/QĐ.UBND 05.12.2013) for a grant awarded to us to finish this work.


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© Springer Science+Business Media B.V., part of Springer Nature 2017

Authors and Affiliations

  • Quang Vinh Nguyen
    • 1
  • San-Lang Wang
    • 2
  • Anh Dzung Nguyen
    • 1
  1. 1.Institute of Biotechnology and EnvironmentTay Nguyen UniversityBuon Ma Thuot CityVietnam
  2. 2.Department of ChemistryTamkang UniversityNew TaipeiTaiwan

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