In vitro α-glucosidase and α-amylase inhibition, and in vivo anti-hyperglycemic effects of Psidium littorale Raddi leaf extract
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Guava, belonging to family Myrtaceae, is widely grown in tropical countries. Different parts of guava are reported to have long been used in folk medicine. In this study, the in vitro and in vivo anti-hyperglycemic activities of Psidium littorale Raddi leaves extract were investigated. The results indicated that the leaf extract demonstrates relatively high intestinal α-glucosidase inhibitory activity in rats, twice as high as acarbose. In addition, the extract also induced lowering fasting blood glucose levels in streptozotocin- induced diabetic rats at the dose of 150 mg/kg body weight, and without any effect on normal rats. Moreover, the extract did not significantly induce body weight loss in rats. The results suggest that P. littorale Raddi may prove to be useful in treating diabetes in humans.
KeywordsAntidiabetic Psidium littorale Raddi DPPH α-amylase α-glucosidase
We would like to express our thanks to the Department of Science and Technology, Dak Lak Province, Vietnam (2550/QĐ.UBND 05.12.2013) for a grant awarded to us to finish this work.
- 5.Y.I. Kwon, D.A. Vattem, K. Shetty, Asia Pac. J. Clin. Nutr. 15, 107 (2005)Google Scholar
- 8.D.C. Elixabet, R.N. Alba, A. Francesca, R. Miguel, V. Vito, S.C. Antonio, D. Juan, G. Julio, Food Res. Int. 6, 64 (2017)Google Scholar
- 11.Y. Deguchi, K. Miyazaki, Nutr. Metab. (Lond) 2, 7 (2010)Google Scholar
- 12.O. Folin, V. Ciocalteu, J. Biol. Chem. 27, 627 (1927)Google Scholar
- 13.Q.V. Nguyen, J.B. Eun, J. Med. Plants Res. 5, 2798 (2011)Google Scholar
- 15.Y.I. Kwon, D.A. Vattem, K. Shetty, Asian Pac. J. Clin. Nutr. 15, 107 (2006)Google Scholar
- 17.OECD, OECD Guidelines for Testing of Chemicals 423: Acute Oral Toxicity-Acute Toxic Class Method (OECD, Paris, 2001)Google Scholar
- 18.S. Ramachandran, K. Asokkumar, M. Uma Maheswari, T.K. Ravi, A.T. Sivashanmugam, S. Saravanan, Evid. Based Complement Alternat. Med. 57, 17 (2011)Google Scholar
- 25.T. Kathirvel, K. Prabhakar, S. Vinoth, S. Sadasivam, B. Thayumanavan, Int. J. Pharm. Sci. Res. 3, 316 (2012)Google Scholar
- 27.M. Gray, Y.H.A. Abdel-Wahab, P.R. Flatt, J. Nutr. 130, 15 (2000)Google Scholar
- 28.C. Palanuvej, S. Hokputsa, T. Tunsaringkarn, N. Ruangrungsi, Thai Med. Plants Sci. Pharm. 77, 837 (2009)Google Scholar