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Efficient and facile protocol for one-pot synthesis of 2-amino-substituted benzothiazoles catalyzed by nano-BF3/SiO2 under mild conditions

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Abstract

A highly efficient and simple protocol for the preparation of 2-aminobenzothiazoles through the reaction of potassium thiocyanate and substituted anilines in the presence of nano-BF3/SiO2 as a reusable heterogeneous catalyst is described. In this method, all of the 2-amino-substituted benzothiazoles were obtained in high to excellent yields and short reaction times under mild conditions. The structures of the resulting products were characterized and confirmed by melting point, FT-IR, 1H NMR and 13C NMR techniques.

Graphical Abstract

A highly efficient and simple protocol for the preparation of 2-aminobenzothiazoles by reaction of potassium thiocyanate and substituted anilines in the presence of nano-BF3/SiO2 as a reusable heterogeneous catalyst is described.

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Acknowledgments

The authors are grateful to the University of Kashan for supporting this work by Grant No. 159148/41.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, 87317, Kashan, Iran

    Hossein Naeimi & Arash Heidarnezhad

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  1. Hossein Naeimi
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  2. Arash Heidarnezhad
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Correspondence to Hossein Naeimi.

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Naeimi, H., Heidarnezhad, A. Efficient and facile protocol for one-pot synthesis of 2-amino-substituted benzothiazoles catalyzed by nano-BF3/SiO2 under mild conditions. Res Chem Intermed 42, 7855–7868 (2016). https://doi.org/10.1007/s11164-016-2566-z

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