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Synthesis of pyranopyrazole derivatives by in situ generation of trityl carbocation under mild and neutral media

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Abstract

In this work, synthesis of pyranopyrazole derivatives by the one-pot tandem four component condensation reaction of aryl aldehydes with ethyl acetoacetate, malononitrile, and hydrazine hydrate in the presence of Ph3CCl at 60 °C under neutral, mild, and solvent-free conditions has been reported. Mechanistically, it is interesting that trityl chloride by in situ generation of trityl carbocation (Ph3C+) promotes the reaction.

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Acknowledgments

The authors gratefully acknowledge support of this work by the Research Affairs Office of Bu-Ali Sina University, Iran National Science Foundation (INSF) (The Grant of Allameh Tabataba’i’s Award) and Sayyed Jamaleddin Asadabadi University.

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Authors and Affiliations

  1. Sayyed Jamaleddin Asadabadi University, Asadabad, 6541835583, Iran

    Ahmad Reza Moosavi-Zare

  2. Faculty of Chemistry, Bu-Ali Sina University, Hamadan, 6517838683, Iran

    Mohammad Ali Zolfigol & Ahmad Mousavi-Tashar

Authors
  1. Ahmad Reza Moosavi-Zare
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  2. Mohammad Ali Zolfigol
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  3. Ahmad Mousavi-Tashar
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Correspondence to Ahmad Reza Moosavi-Zare or Mohammad Ali Zolfigol.

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Moosavi-Zare, A.R., Zolfigol, M.A. & Mousavi-Tashar, A. Synthesis of pyranopyrazole derivatives by in situ generation of trityl carbocation under mild and neutral media. Res Chem Intermed 42, 7305–7312 (2016). https://doi.org/10.1007/s11164-016-2537-4

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