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Synthesis and biological evaluation of new series 1,4-dihydropyridines

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Abstract

N,N,N′,N′-Tetrachlorobenzene-1,3-disulfonamide and poly(N,N′-dichloro-N-ethyl-benzene-1,3-disulfonamide) are new catalysts promoted by one-pot, facile and four-component synthesis of new substituted 1,4-dihydropyridine derivatives from the reaction of ammonium acetate, aldehydes and various 1,3-dicarbonyl compounds with good to high yields at room temperature under mild conditions. All the synthesized compounds were evaluated for antibacterial and anti-oxidant activities. Antibacterial activity was determined against four Gram-positive and -negative bacteria, and anti-oxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl free radical scavenging. The bioassay results indicated that synthesized 1,4-dihydropyridine derivatives have effective anti-oxidant and antibacterial functions.

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Synthesis and biological evaluation of new series dihydropyridines.

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Acknowledgment

We are grateful to Bu-Ali Sina University, Center of Excellence and Development of Chemical Methods (CEDCM) for financial support.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, 65174, Hamedan, Iran

    Ramin Ghorbani-Vaghei & Seyedeh Mina Malaekehpoor

  2. Department of Biology, Faculty of Science, Bu-Ali Sina University, 65174, Hamedan, Iran

    Parisa Hasanein, Roya Karamyan & Mostafa Asadbegy

Authors
  1. Ramin Ghorbani-Vaghei
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  2. Seyedeh Mina Malaekehpoor
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  3. Parisa Hasanein
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  4. Roya Karamyan
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  5. Mostafa Asadbegy
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Corresponding author

Correspondence to Ramin Ghorbani-Vaghei.

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Ghorbani-Vaghei, R., Malaekehpoor, S.M., Hasanein, P. et al. Synthesis and biological evaluation of new series 1,4-dihydropyridines. Res Chem Intermed 42, 4715–4731 (2016). https://doi.org/10.1007/s11164-015-2310-0

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