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An efficient synthesis of anti-microbial 1,2,4-triazole-3-thiones promoted by acidic ionic liquid

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Abstract

Acidic ionic liquid, [(Py)2SO][HSO4]2 has been used as an efficient catalyst for the reaction of ketone with thiosemicarbazide in ethanol at room temperature for the eco-friendly synthesis of spiro-1,2,4-triazolidine-3-thiones. Smooth reactions, ambient temperature, use of alcohol as a solvent, high yields, easy work-up procedure and excellent recyclability of ionic liquid and high atom economy are the auxiliary advantages of the present protocol, which makes it ecofriendly. All the synthesized 1,2,4-trioazoles were screened for antimicrobial activity. Most of compounds displayed moderate to good biological activity.

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Acknowledgments

Author DMP thanks DST Fast Track Scheme New Delhi for financial assistance (No. SB/FT/CS-154/2012).

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Authors and Affiliations

  1. Department of Chemistry, Shivaji University, Kolhapur, 416 004, India

    Pradeep B. Patil, Jayavant D. Patil, Suyog N. Korade & Dattaprasad M. Pore

  2. Department of Bio-Chemistry, Shivaji University, Kolhapur, 416 004, India

    Siddheshwar D. Kshirsagar & Sanjay P. Govindwar

Authors
  1. Pradeep B. Patil
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  2. Jayavant D. Patil
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  3. Suyog N. Korade
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  4. Siddheshwar D. Kshirsagar
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  5. Sanjay P. Govindwar
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  6. Dattaprasad M. Pore
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Corresponding authors

Correspondence to Sanjay P. Govindwar or Dattaprasad M. Pore.

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Patil, P.B., Patil, J.D., Korade, S.N. et al. An efficient synthesis of anti-microbial 1,2,4-triazole-3-thiones promoted by acidic ionic liquid. Res Chem Intermed 42, 4171–4180 (2016). https://doi.org/10.1007/s11164-015-2267-z

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  • DOI: https://doi.org/10.1007/s11164-015-2267-z

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