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Synthesis, characterization and antimicrobial screening of thiazole based 1,3,4-oxadiazoles heterocycles

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Abstract

In an effort to find a new pharmacologically dynamic molecule, we report here the synthesis and in vitro antimicrobial activity of various N-(4-methyl-5-(4-((substituted phenylamino) methyl)-5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)thiazol-2-yl) benzamides. The structures of newly synthesized compounds were assigned on the bases of IR, 1H NMR, 13C NMR, and mass spectral data. Synthesized compounds were screened for their antibacterial and antifungal activities on gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes), gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and three fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) by serial broth dilution method. Compounds 5e and 5k were associated with considerable potential antibacterial and compounds 5a and 5b antifungal activities.

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Acknowledgments

The authors are thankful to the University Grants Commission, New Delhi and Department of Science and Technology, New Delhi for financial support under the NON-SAP and DST-FIST programs, respectively.

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Authors and Affiliations

  1. Division of Medicinal Chemistry, Department of Chemistry, Maharaja Krishnakumarsinhji Bhavnagar University, Mahatma Gandhi Campus, Bhavnagar, 364002, India

    N. C. Desai, Nayan Bhatt, Amit Dodiya, Tushar Karkar, Bonny Patel & Malay Bhatt

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  1. N. C. Desai
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  2. Nayan Bhatt
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Correspondence to N. C. Desai.

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Desai, N.C., Bhatt, N., Dodiya, A. et al. Synthesis, characterization and antimicrobial screening of thiazole based 1,3,4-oxadiazoles heterocycles. Res Chem Intermed 42, 3039–3053 (2016). https://doi.org/10.1007/s11164-015-2196-x

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  • DOI: https://doi.org/10.1007/s11164-015-2196-x

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