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Microwave-assisted synthesis of novel pyrazole and pyrazolo[3,4-d]pyridazine derivatives incorporating diaryl sulfone moiety as potential antimicrobial agents

Abstract

We present a novel, facile and efficient methodology for the synthesis of pyrazoles and pyrazolo[3,4-d]pyridazines linked to diaryl sulfone moiety using synthetic talc as a solid base catalyst under microwave irradiation, via 1,3-dipolar cycloaddition reaction of the E-3-(dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one with different hydrazonyl halides. All synthesized compounds were evaluated for antibacterial and antifungal activities. The results showed that most of the synthesized compounds exhibited promising antimicrobial activities.

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Correspondence to Mohamed F. Mady.

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Mady, M.F., Saleh, T.S., El-Kateb, A.A. et al. Microwave-assisted synthesis of novel pyrazole and pyrazolo[3,4-d]pyridazine derivatives incorporating diaryl sulfone moiety as potential antimicrobial agents. Res Chem Intermed 42, 753–769 (2016). https://doi.org/10.1007/s11164-015-2054-x

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Keywords

  • Solvent-free reactions
  • Microwave irradiation
  • Synthetic talc
  • Diaryl sulfone
  • Regioselectivity
  • Pyrazolo[3,4-d]pyridazines
  • Antimicrobial activity