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Solvent-free silica-promoted multicomponent condensation: synthesis of highly functionalized piperidines

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Abstract

Silica gel has been found to be an efficient and reusable medium for the synthesis of diastereospecific functionalized piperidines in good to high yields by a one-pot three-component condensation of aldehyde, amine and β-ketoester under solvent-free conditions at room temperature. Using this environmentally benign, non-inflammable and non-toxic reaction medium, the non-chromatographic purification, reusability of the silica gel, and operational simplicity are the notable advantages of the present method. The procedure is applicable for large-scale synthesis of piperidines derivatives and represents a green synthetic protocol.

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Acknowledgments

A.H. and A.M. acknowledge the financial support from CSIR, Govt. of India (Grant No. 02(0168)/13/EMR-II). We are grateful to DST-FIST and UGC-SAP. A.K.B. and S.S. thank CSIR and UGC for their fellowships.

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Authors and Affiliations

  1. Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India

    Sudarshan Das, Avik Kumar Bagdi, Sougata Santra, Adinath Majee & Alakananda Hajra

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  1. Sudarshan Das
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  2. Avik Kumar Bagdi
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  3. Sougata Santra
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Correspondence to Alakananda Hajra.

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Das, S., Bagdi, A.K., Santra, S. et al. Solvent-free silica-promoted multicomponent condensation: synthesis of highly functionalized piperidines. Res Chem Intermed 41, 6749–6763 (2015). https://doi.org/10.1007/s11164-014-1774-7

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