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Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}

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Abstract

A new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)} has been synthesized, characterized by elemental analysis, MS, IR, and 1H, 13C NMR, and evaluated for in vitro anticancer activity in four human cancer cell lines. The stability of the derivative in water was also investigated by monitoring the changes of 1H NMR in D2O. The results reveal that the new derivative has good solubility and stability in water and also shows high anticancer activity against gastric cancer cells, ovarian cancer cells, and colon cancer cells. Therefore, it is worthy of further evaluation for in vivo antitumor activity and toxicity.

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Acknowledgments

The authors are grateful to the National Science Foundation of P. R. China (Grant No. 21161010) and China National Research and Development Program (Grant No. 2012BAE06B08) for financial support.

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Authors and Affiliations

  1. State Key Lab of Advanced Technologies for PGM, Kunming Institute of Precious Metals, Kunming, 50106, China

    Jing Jiang, Xi-Zhu Chen, Qing-Song Ye, Qiao-Wen Chang & Wei-Ping Liu

  2. School of Chemistry, Hunan Normal University, Changsha, 410081, China

    Jing Lei

  3. Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, China

    Li-Guang Lou & Yong-Ping Xu

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  1. Jing Jiang
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  2. Jing Lei
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  3. Xi-Zhu Chen
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Correspondence to Wei-Ping Liu.

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Jiang, J., Lei, J., Chen, XZ. et al. Synthesis and anticancer activity of a new water-soluble derivative of heptaplatin, cis-{Pt(II)[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane](3-acetoxyl-cyclobutane-1,1-dicarboxylato)}. Res Chem Intermed 41, 6149–6155 (2015). https://doi.org/10.1007/s11164-014-1728-0

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  • DOI: https://doi.org/10.1007/s11164-014-1728-0

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