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Synthesis of imidazolinone and benzoxazole derivatives, and evaluation of their anticancer activity

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Abstract

A series of imidazolinone and benzoxazole derivatives (3 and 5) have been synthesized by condensation of oxazolinone derivatives (2a–c) with aniline and 2-hydroxyaniline. Acetyl derivatives (4 and 6) were prepared by acetylation of compounds 3 and 5 with acetic anhydride. Reaction of compound 5 with chloroacetyl chloride produced chloroacetyl derivative 7. The results revealed that the imidazolinone and benzoxazole derivatives had potent activity against cancer cell lines MCF-7 and HePG2, and that the benzoxazole derivatives were more potent than imidazolinone derivatives.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science (for Girls), Al-Azhar University, Nasr City, Egypt

    Heba A. El-Hady

  2. Chemistry Department, Faculty of Applied Science, Umm al Qura University, Mecca, Saudi Arabia

    Heba A. El-Hady

  3. Chemistry Department, Girls College of Science, University of Dammam, Dammam, Saudi Arabia

    Samar A. Abubshait

Authors
  1. Heba A. El-Hady
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  2. Samar A. Abubshait
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Correspondence to Heba A. El-Hady.

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El-Hady, H.A., Abubshait, S.A. Synthesis of imidazolinone and benzoxazole derivatives, and evaluation of their anticancer activity. Res Chem Intermed 41, 1833–1841 (2015). https://doi.org/10.1007/s11164-013-1464-x

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  • DOI: https://doi.org/10.1007/s11164-013-1464-x

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