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Convenient synthesis of naphtho[1,6] naphthyridine derivatives under catalyst-free conditions

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Abstract

A three-component reaction of aromatic aldehyde, naphthalene-2-amine or naphthalen-1-amine, and tert-butyl 2,4-dioxopiperidine-1-carboxylate in reflux EtOH, gave naphtho[1,6]naphthyridine derivatives in high yields under catalyst-free conditions.

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Acknowledgments

We are grateful to the National Natural Science foundation of China (20802061, 21104064), a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions, Qing Lan Project (10QLD008, GSFM2011003, 12ssjcxyb05) and College Industrialization Project (JHB2012-31) of Jiangsu Province for financial support.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou Jiangsu, 221116, People’s Republic of China

    Xing-Ye Mu, Jing Xu, Yu-Jing Zhou, Yu-Ling Li, Yun Liu & Xiang-Shan Wang

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  1. Xing-Ye Mu
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  2. Jing Xu
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  3. Yu-Jing Zhou
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Correspondence to Xiang-Shan Wang.

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Mu, XY., Xu, J., Zhou, YJ. et al. Convenient synthesis of naphtho[1,6] naphthyridine derivatives under catalyst-free conditions. Res Chem Intermed 41, 1703–1714 (2015). https://doi.org/10.1007/s11164-013-1305-y

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