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A rapid and an efficient synthesis for 3,5-disubstituted 1,2,4-oxadiazoles under microwave irradiation

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Abstract

The one-pot, three-component reaction of aromatic nitriles, hydroxylamine hydrochloride, and sodium carbonate in ethylene glycol provided 3,5-disubstituted 1,2,4-oxadiazoles. These 1,2,4-oxadiazole derivatives are quickly prepared under microwave irradiation (2 h) in high yields and excellent state of purity. The synthesized compounds were characterized by means of their 1H, 13C NMR, mass spectroscopy data and elemental analysis.

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Authors and Affiliations

  1. Unité de Catalyse et de Chimie du Solide (UCCS), CNRS UMR 8181, ENSCL Université Lille Nord de France, BP 90108, 59652, Villeneuve d’Ascq Cedex, France

    Moha Outirite & Michel Lagrenée

  2. LCAE-URAC18, Faculté des Sciences, Université Mohammed Ier, BP 717, 60000, Oujda, Morocco

    Belkheir Hammouti

  3. Laboratoire de Catalyse et de Corrosion des Matériaux (LCCM), Faculté des Sciences, Université Chouaib Doukkali, BP 20, 24000, El Jadida, Morocco

    Fouad Bentiss

Authors
  1. Moha Outirite
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  2. Michel Lagrenée
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  3. Belkheir Hammouti
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  4. Fouad Bentiss
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Correspondence to Belkheir Hammouti.

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Outirite, M., Lagrenée, M., Hammouti, B. et al. A rapid and an efficient synthesis for 3,5-disubstituted 1,2,4-oxadiazoles under microwave irradiation. Res Chem Intermed 41, 1601–1606 (2015). https://doi.org/10.1007/s11164-013-1296-8

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  • DOI: https://doi.org/10.1007/s11164-013-1296-8

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