Synthesis and antimicrobial activity of novel chalcone derivatives
- 614 Downloads
A series of novel 3-[N, N-bis(2-hydroxyethyl)-amino]-chalcone derivatives 3a–3j were synthesized by the aldol condensation of [N, N-bis(2-hydroethyl)-3-amino]-acetophenone 2 with aromatic aldehydes. Their structures were further confirmed by ESI-HRMS, 1H NMR, IR and elemental analysis. X-ray analysis reveals crystal 3b is a monoclinic system with P21/n space group. The antimicrobial activities of the newly synthesized chalcones in vitro were evaluated and the results indicated that most compounds presented moderate to good antimicrobial activities, especially the antifungal capability. Compounds 3a, 3d, 3f and 3g revealed obvious potency against Candida albicans with MIC values of 32 μg/mL, which were better compared with others.
KeywordsChalcone Synthesis Crystal structure Broth tube dilution method Antimicrobial activity
- 9.B. Madan, S. Batra, B. Ghosh, Mol. Pharmacol. 58, 526 (2000)Google Scholar
- 12.J.R. Wingard, H.L. Leather, Oncol. 15, 351 (2001)Google Scholar
- 17.NCCLS, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically M7-A5, vol. 20 (National Committee on Clinical Laboratory Standards, Wayne, 2000), p. 2Google Scholar
- 21.G.H. Wu, L. Wang, S.M. Wang, L. Li, X.Y. Xu, J.X. Yang, Chin. J. Syn. Chem. 17, 503 (2009). (in Chinese)Google Scholar