Abstract
Efficient three-component synthesis of pyranopyrazole derivatives by reacting substituted aromatic aldehydes (1), (4-chlorophenyl)acetonitrile (2) and 3-methyl-1H-pyrazol-5(4H)-one (3) using bleaching earth clay (pH 12.5) as heterogeneous catalyst and PEG-400 as green solvent is reported in the present communication. The reaction time and product yields are excellent. Catalyst and solvent recovery and reusability are very good. This is a simple, green and rapid method for synthesis of pyranopyrazole derivatives.
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Acknowledgments
Financial support for this project under UGC SAP project no F. 3-36/2011 (SAP-II) is greatly acknowledged. R.D.K. and S.D.P. are grateful to CSIR New Delhi for JRF.
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Kamble, R.D., Dawane, B.S., Yemul, O.S. et al. Bleaching earth clay (pH 12.5): a green catalyst for rapid synthesis of pyranopyrazole derivatives via a tandem three-component reaction. Res Chem Intermed 39, 3859–3866 (2013). https://doi.org/10.1007/s11164-012-0887-0
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DOI: https://doi.org/10.1007/s11164-012-0887-0