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POM as a quick bioinformatic platform to select flavonoids and their metabolites as potential and efficient HIV-1 integrase inhibitors

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Abstract

This paper surveys the various naturally occurring flavonoids that have been isolated from different natural sources. This is the first petra/osiris/molinspiration (POM) analysis published on this topic. The present study furnishes an overview of the 32 flavonoids and anti-HIV-Integrase activity of their metabolite species. The aqueous and/or ethanol extraction of flavonoids have often been used in traditional medicine, and therefore have also been studied for their antitumor, antioxidant, antiviral, anti-algal, antimicrobial, cytotoxic and anti-inflammatory, and significant hepatoprotective and cardiovascular activity without any criteria of selection. Here, on the basis of POM analyses, a simple, economic, quick and efficient bioinformatic platform, it now becomes easy and possible to predict and optimize flavonoids bioactivity.

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Authors and Affiliations

  1. Laboratoire Chimie Matériaux, Faculté des Sciences, Université Med. I, Oujda, Morocco

    Taibi Ben Hadda

  2. Laboratoire de Chimie Physique des Biomolécules et Interfaces biologiques, Faculté des Sciences de la Nature et de la Vie, Université de Mascara, 29000, Mascara, Algeria

    Teffaha Fergoug

  3. Department of Chemistry, Science College, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia

    Ismail Warad

  4. Department of Chemistry, Vidyabharati College of Pharmacy, Camp Amaravati, Maharashtra, India

    Vijay Masand

  5. National Environmental Engineering Research Institute, Nagpur, 440020, India

    Javed Sheikh

Authors
  1. Taibi Ben Hadda
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  2. Teffaha Fergoug
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  3. Ismail Warad
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  4. Vijay Masand
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  5. Javed Sheikh
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Corresponding author

Correspondence to Taibi Ben Hadda.

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Highlights

1. POM approach provides an intelligent, economic and quick method of identifying hits. 2. Flavonoids which may be modulated to inhibit viral HIV replication. 3. Elucidation of antiviral mechanism of flavonoids for treating viral infections.

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Hadda, T.B., Fergoug, T., Warad, I. et al. POM as a quick bioinformatic platform to select flavonoids and their metabolites as potential and efficient HIV-1 integrase inhibitors. Res Chem Intermed 39, 1227–1244 (2013). https://doi.org/10.1007/s11164-012-0679-6

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  • DOI: https://doi.org/10.1007/s11164-012-0679-6

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