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Pharmacological evaluation of benzimidazole derivatives with potential antiviral and antitumor activity

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Abstract

In recent years the synthesis of benzimidazole and its derivatives has attracted the attention of many organic chemists because of the compounds’ interesting biological activity and the crucial importance of the benzimidazole unit in the function of these biologically important molecules. Benzimidazole-based polyheterocyclic compounds have several interesting biological properties. Simple synthetic strategies leading to benzimidazole-based fused polyheterocyclic systems and the antiviral and anticancer biological activity of the compounds are surveyed in this review article.

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Authors and Affiliations

  1. Department of Chemistry of Natural and Microbial Products, National Research Centre, 12622, Cairo, Egypt

    Sherifa M. Abu-Bakr

  2. Department of Chemistry of Natural and Microbial Products and Pharmaceutical Research, Center of Excellence for Advanced Sciences, National Research Centre, 12622, Cairo, Egypt

    Fatma A. Bassyouni

  3. Department of Analytical Chemistry, Stockholm University, 10691, Stockholm, Sweden

    Mohamed Abdel Rehim

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  1. Sherifa M. Abu-Bakr
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Abu-Bakr, S.M., Bassyouni, F.A. & Rehim, M.A. Pharmacological evaluation of benzimidazole derivatives with potential antiviral and antitumor activity. Res Chem Intermed 38, 2523–2545 (2012). https://doi.org/10.1007/s11164-012-0569-y

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