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Photochemical synthesis and antimicrobial screening of some substituted dihydrobenzofurans

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Abstract

Dihydrobenzofurans containing carbomethoxy-ethenyl at 2-position and phenyl and hydroxyl at 3-position were synthesized by photochemical methods and screened for antibacterial activity. These dihydrobenzofurans were moderately active against bacteria, both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa), while compound 3-(6-chloro-3-hydroxy-3-phenyl-2,3-dihydrobenzofuran-2-yl)acrylic acid methyl ester showed promising activity against both the Gram-positive and Gram-negative bacteria.

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Acknowledgment

One of the authors, K. Selvam, is thankful to CSIR, New Delhi for the award of Senior Research Fellowship.

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Authors and Affiliations

  1. Department of Chemistry, Annamalai University, Annamalainagar, 608 002, Tamilnadu, India

    K. Ravi, K. Selvam & M. Swaminathan

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  1. K. Ravi
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  2. K. Selvam
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  3. M. Swaminathan
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Correspondence to M. Swaminathan.

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Ravi, K., Selvam, K. & Swaminathan, M. Photochemical synthesis and antimicrobial screening of some substituted dihydrobenzofurans. Res Chem Intermed 38, 2393–2400 (2012). https://doi.org/10.1007/s11164-012-0555-4

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  • DOI: https://doi.org/10.1007/s11164-012-0555-4

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