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Quinoline-3-carboxylates as potential antibacterial agents

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Abstract

The ethyl-2-chloroquinoline-3-carboxylates, 4, were achieved from o-aminobenzophenones in two steps. i.e. initially, the ethyl-2-oxoquinoline-3-carboxylates, 3, were obtained by base-catalyzed Friedlander condensations of o-aminobenzophenones, 1, and diethylmalonate, 2. The 2-chloroquinoline-3-carboxylates, 4, were then obtained by the reaction with POCl3 in good yields. The chemical structures were confirmed by FTIR, mass and 1H-NMR spectroscopic techniques. All the synthesized compounds were tested for their in vitro antibacterial activity against Bacillus subtilis and Vibrio cholera and found to possess moderate activity.

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Acknowledgments

Authors are grateful to VIT University, Vellore, for providing research facilities. The authors wish to express their gratitude to SAIF, Indian Institute of Technology, Chennai, for their support of NMR and HRMS.

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Authors and Affiliations

  1. Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632014, Tamil Nadu, India

    V. Krishnakumar, Fazlur-Rahman Nawaz Khan, Sukanya Mitta, Ramu Dhasamandha & Vindhya Nanu Govindan

  2. Environmental and Analytical Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632014, Tamil Nadu, India

    V. Krishnakumar & Badal Kumar Mandal

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  1. V. Krishnakumar
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  2. Fazlur-Rahman Nawaz Khan
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  3. Badal Kumar Mandal
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  4. Sukanya Mitta
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  5. Ramu Dhasamandha
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  6. Vindhya Nanu Govindan
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Correspondence to Fazlur-Rahman Nawaz Khan.

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Krishnakumar, V., Khan, FR.N., Mandal, B.K. et al. Quinoline-3-carboxylates as potential antibacterial agents. Res Chem Intermed 38, 1819–1826 (2012). https://doi.org/10.1007/s11164-012-0505-1

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  • DOI: https://doi.org/10.1007/s11164-012-0505-1

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