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Determination of catalytic oxidation products of phenol by RP-HPLC

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Abstract

A reversed-phase high-performance liquid chromatography (RP-HPLC) with ultraviolet detection was established for the determination of phenol, catechol, hydroquinone, and p-benzoquinone in the reaction solution of catalytic oxidation of phenol using hydrogen peroxide as the oxidant and copper-doped FeSBA-15 zeolite as the catalyst. Separation was accomplished on a reversed-phase C18 column, and the elution condition was optimized by changing the composition of the mobile phase. A good resolution of all of the relative components in the reaction solution was achieved when the mobile phase was methanol–water–1% acetic acid aqueous solution = 10:50:40 (v/v/v). The concentrations of phenol, catechol, hydroquinone, and p-benzoquinone were determined in 11 different reaction solutions by the external standard method. The proposed HPLC method was simple, accurate, reliable, and suitable for tracing the amount of target products during the catalytic oxidation reaction of phenol. The results can provide data support for evaluating the properties of catalysts, and, thus, guide the selection of catalysts for the industrial production of dihydric phenol.

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Acknowledgment

This study was supported by the National Natural Science Foundation of China (90913012, 20873060, 20973091), the National Basic Research Program of China (973 program, 2009CB421601, 2011CB911003, 2009CB623500), National Science Funds for Creative Research Groups (20821063), and the Analysis & Test Fund and Starting Fund for Young Teachers of the Center of Materials Analysis, Nanjing University.

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Authors and Affiliations

  1. Center of Materials Analysis, Nanjing University, 22 Hankou Road, Nanjing, 210093, China

    Jun-Qin Qiao, Hong-Zhen Lian & Lin Dong

  2. State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, 22 Hankou Road, Nanjing, 210093, China

    Jun-Qin Qiao, Na Yuan, Jing Yang, Jian Zhou & Hong-Zhen Lian

  3. Key Laboratory of Mesoscopic Chemistry, Ministry of Education of China, Nanjing University, 22 Hankou Road, Nanjing, 210093, China

    Chang-Jin Tang & Lin Dong

  4. School of Chemistry & Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing, 210093, China

    Na Yuan, Chang-Jin Tang, Jing Yang, Jian Zhou, Hong-Zhen Lian & Lin Dong

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  1. Jun-Qin Qiao
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  2. Na Yuan
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  3. Chang-Jin Tang
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  7. Lin Dong
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Correspondence to Hong-Zhen Lian or Lin Dong.

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Qiao, JQ., Yuan, N., Tang, CJ. et al. Determination of catalytic oxidation products of phenol by RP-HPLC. Res Chem Intermed 38, 549–558 (2012). https://doi.org/10.1007/s11164-011-0370-3

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  • DOI: https://doi.org/10.1007/s11164-011-0370-3

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