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An efficient one pot–three component cyclocondensation in the synthesis of 2-(2-chloroquinolin-3-yl)-2,3-dihydroquinazolin-4(1H)-ones: potential antitumor agents

Abstract

Montmorillonite K10 efficiently catalyzed a one pot–three component cyclocondensation of isatoic anhydride, NH4OAc and aromatic/heteroaromatic aldehydes under ambient conditions to produce the corresponding 2-substituted-2,3-dihydroquinazolin-4(1H)-ones in good yields. The 2-(2-chloroquinolin-3-yl)-2,3-dihydroquinazolin-4(1H)-ones 3a–d were screened for their antitumor activity against Ehrlich Ascites Carcinoma tumor cells

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Fig. 1
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Acknowledgments

This work was supported by Department of Science & Technology Government of India (Grant No. SR/FTP/CS-99/2006). We also acknowledge SAIF, IIT Madras, Chennai for providing NMR and MS facility. The authors are grateful to the VIT University management for their generous support and facilities.

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Correspondence to F. Nawaz Khan.

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Roopan, S.M., Nawaz Khan, F., Jin, J.S. et al. An efficient one pot–three component cyclocondensation in the synthesis of 2-(2-chloroquinolin-3-yl)-2,3-dihydroquinazolin-4(1H)-ones: potential antitumor agents. Res Chem Intermed 37, 919–927 (2011). https://doi.org/10.1007/s11164-011-0301-3

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  • DOI: https://doi.org/10.1007/s11164-011-0301-3

Keywords

  • Montmorillonite K10
  • Dihydroquinazolin-4(1H)-one
  • Antitumor studies