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Cycloalkyl substituted N-nitrourea derivatives: a convenient synthesis and biological evaluation

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Abstract

A series of N-nitrourea derivatives bearing various cycloalkyl were conveniently obtained via three steps including nitration, carbamic chlorination, and aminolysis reactions. The structures of all newly synthesized compounds were elucidated and confirmed by IR, 1H NMR, 13C NMR, and elemental analysis. The preliminary bioassay indicated that the target compounds exhibited moderate herbicidal activity against Amaranthus albus and Sorghum sudanense. However, some of the title compounds presented high plant growth regulating activity against rice.

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Acknowledgments

The author gratefully acknowledge the financial support from the Academic Discipline-Crossed Project (2010JC001) and the Research Initiation Funds (2009BQ027) of the Huazhong Agricultural University.

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Authors and Affiliations

  1. College of Science, Huazhong Agricultural University, Wuhan, 430070, People’s Republic of China

    Zhongyuan Bai, Zengjun Wei, Yunchun Wang, Shengzhen Xu & Changshui Chen

  2. Department of Applied Chemistry, Biochemical Institute, Huazhong Agricultural University, Wuhan, 430070, People’s Republic of China

    Xuegang Li & Xiufang Cao

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  1. Zhongyuan Bai
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  2. Zengjun Wei
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  3. Yunchun Wang
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  4. Shengzhen Xu
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  5. Xuegang Li
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  6. Changshui Chen
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  7. Xiufang Cao
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Correspondence to Changshui Chen or Xiufang Cao.

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Bai, Z., Wei, Z., Wang, Y. et al. Cycloalkyl substituted N-nitrourea derivatives: a convenient synthesis and biological evaluation. Res Chem Intermed 37, 859–868 (2011). https://doi.org/10.1007/s11164-011-0293-z

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  • DOI: https://doi.org/10.1007/s11164-011-0293-z

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