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An example of quality control of fine chemical intermediates: related impurity analysis of industrial phthalic anhydride by reversed-phase high-performance liquid chromatography

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Abstract

A reliable reversed-phase high-performance liquid chromatographic method has been developed for analysis of related impurities in industrial phthalic anhydride (PA). Maleic acid (hydrolysis product of maleic anhydride), phthalimide, and benzoic acid were separated from phthalic acid (Pa, hydrolysis product of PA) on a C18 column by gradient elution with acetonitrile and 0.1% (v/v) aqueous perchloric acid solution. This method is simple, sensitive, and accurate, and has been successfully applied to quality control of PA for industrial use.

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Acknowledgments

This work was supported by the National Basic Research Program of China (973 program, 2009CB421601, 2011CB911003), the National Natural Science Foundation of China (20575027, 90913012), the National Science Funds for Creative Research Groups (20821063), and the Analysis and Test Fund of Nanjing University.

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Authors and Affiliations

  1. Key Laboratory of Analytical Chemistry for Life Science (Ministry of Education of China), School of Chemistry and Chemical Engineering and Center of Materials Analysis, Nanjing University, 22 Hankou Road, Nanjing, 210093, China

    Lin-feng Zhou, Jun-qin Qiao, Hong-zhen Lian & Xin Ge

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  1. Lin-feng Zhou
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  2. Jun-qin Qiao
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  3. Hong-zhen Lian
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  4. Xin Ge
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Correspondence to Hong-zhen Lian or Xin Ge.

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Zhou, Lf., Qiao, Jq., Lian, Hz. et al. An example of quality control of fine chemical intermediates: related impurity analysis of industrial phthalic anhydride by reversed-phase high-performance liquid chromatography. Res Chem Intermed 37, 617–625 (2011). https://doi.org/10.1007/s11164-010-0234-2

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  • DOI: https://doi.org/10.1007/s11164-010-0234-2

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