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A rapid synthetic method of pyridobenzodiazepines

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Abstract

A new one-pot Bischler–Napeiralski type cyclization reaction between pyridine-1,2-diamines and various carboxylic acids with PPA as catalyst to prepare pyridobenzodiazepines is proposed. In the new synthetic route, the reaction time is only one-third of the methods reported. The synthetic strategy provides an efficient way to prepare novel structurally diversified heterocyclic compounds of pyridobenzodiazepine family with potential pharmaceutical or biological activities.

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Authors and Affiliations

  1. Jilin Provincial Engineering Laboratory for the Complex Utilization of Petroresource and Biomass, 2055 Yanan St., Changchun, 130012, Jilin, People’s Republic of China

    Fuqiang Shi & Long Zhang

  2. The Center for Combinatorial Chemistry and Drug Discovery, Jilin University, 75 Haiwai St., Changchun, 130012, Jilin, People’s Republic of China

    Xu Bai & Qun Dang

Authors
  1. Fuqiang Shi
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  2. Xu Bai
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  3. Qun Dang
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  4. Long Zhang
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Correspondence to Fuqiang Shi or Long Zhang.

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Shi, F., Bai, X., Dang, Q. et al. A rapid synthetic method of pyridobenzodiazepines. Res Chem Intermed 36, 253–258 (2010). https://doi.org/10.1007/s11164-010-0135-4

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  • DOI: https://doi.org/10.1007/s11164-010-0135-4

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